Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

Abstract

The present study aimed to determine whether Nicotiflorin, a natural flavonoid extracted from coronal of Carthamus tinctorius, has a protective effect on cerebral multi-infarct dementia in rats. The multi-infarct dementia model rats were prepared by injecting man-made micro-thrombi into the right hemisphere. The administration groups were treated once daily with 30, 60 and 120 mg/kg Nicotiflorin (i.g.) from 5 days before ischemia operation to 3 days after the operation for biochemical examination, 10 days for Morris water maze study and morphological observations and 20 days for eight-arm radial maze task. 2,3,5-triphenyltetrazolium chloride (TTC) staining showed that infarct volume of each Nicotiflorin administration group was much smaller than that of vehicle-treated multi-infarct dementia group, and hematoxylin and eosin (HE) staining showed that histopathological abnormalities of each Nicotiflorin group were also much lighter than that of vehicle-treated multi-infarct dementia group. Each Nicotiflorin group showed much better spatial memory performance in Morris water maze tests and eight-arm radial maze task compared with the vehicle-treated multi-infarct dementia group, significantly attenuated the elevation of lactic acid and malondialdehyde (MDA) contents and the decrease in lactate dehydrogenase (LDH), Na(+)K(+)ATPase, Ca(2+)Mg(2+)ATPase and superoxide dismutase (SOD) activity in the brain tissue which was composed of striatum, cortex and hippocampus of the ischemia hemisphere at day 3 after ischemia operation. These results suggest that Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

• Authors: Jin-Ling Huang, Shou-Ting Fu, Yuan-Ying Jiang, Yong-Bing Cao, Mei-Li Guo, Yan Wang, Zheng Xu
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 86 Issue 4 Pg. 741-8 (Apr 2007) ISSN: 0091-3057 [Print] United States
• PMID: 17448528 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flavonoids
• Neuroprotective Agents
• Phenols
• nicotiflorin

Topics

• Animals
• Brain (drug effects, metabolism, pathology)
• Dementia, Multi-Infarct (drug therapy, metabolism, pathology, psychology)
• Disease Models, Animal
• Energy Metabolism (drug effects)
• Flavonoids (pharmacology)
• Male
• Maze Learning (drug effects)
• Memory Disorders (drug therapy)
• Neuroprotective Agents (pharmacology)
• Oxidative Stress (drug effects)
• Phenols (pharmacology)
• Rats
• Rats, Sprague-Dawley