Abstract | BACKGROUND: RESULTS: Children with T1DM (84 male, 65 female) had a mean age of 8.7 +/- 4.3 yr and a racial background of 78% white, 19% black, and 3% other. In contrast, children with T2DM (13 female, 13 male) had a mean age of 14.2 +/- 3.1 yr with a racial background of 58% black, 27% white, and 15% other. Fasting C-peptide level was 0.38 +/- 0.37 ng/mL in T1DM vs. 2.66 +/- 2.14 ng/mL in T2DM; a C-peptide of 0.85 ng/mL had 83% sensitivity in distinguishing T1DM from T2DM. Fasting IGFBP-1 level was 38.1 +/- 39.1 ng/mL (T1DM) vs. 3.6 +/- 4.5 ng/mL (T2DM); a value of 3.6 ng/dL could distinguish the two types of diabetes with 93% sensitivity. Urinary ketones were found in 79% of children with T1DM compared with 56% of those with T2DM, and the magnitude was associated with type of diabetes. Initial CO(2) level for T1DM was 17.9 +/- 6.9 mmol/L vs. 22.7 +/- 5.7 mmol/L for T2DM; a value of 21.5 mmol/L could distinguish the two types of diabetes with 83% sensitivity. CONCLUSIONS: In addition to obesity, family history of T2DM, and absence of GAD-65 antibodies, children with new-onset T2DM may be distinguished from those with T1DM by a combination of biochemical parameters ( C-peptide, IGFBP-1, CO(2), and urine ketones).
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Authors | Lorraine E Levitt Katz, Abbas F Jawad, Jaya Ganesh, Máire Abraham, Kathryn Murphy, Terri H Lipman |
Journal | Pediatric diabetes
(Pediatr Diabetes)
Vol. 8
Issue 2
Pg. 53-9
(Apr 2007)
ISSN: 1399-543X [Print] Denmark |
PMID | 17448127
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- C-Peptide
- Insulin-Like Growth Factor Binding Protein 1
- Ketones
- Carbon Dioxide
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Topics |
- Adolescent
- Biomarkers
(blood)
- C-Peptide
(blood)
- Carbon Dioxide
(blood)
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
(blood, diagnosis)
- Diabetes Mellitus, Type 2
(blood, diagnosis)
- Diagnosis, Differential
- Female
- Humans
- Insulin-Like Growth Factor Binding Protein 1
(blood)
- Ketones
(urine)
- Male
- Obesity
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