Early chronic administration of propranolol reduces the severity of portal hypertension and portal-systemic shunts in conscious portal vein stenosed rats.

Abstract	We investigated the effects of early chronic administration of propranolol on systemic and splanchnic hemodynamic changes, and the development of portal-systemic shunts in conscious, unrestrained, portal vein stenosed rats. Compared to rats receiving placebo, early chronic propranolol (75 mg kg-1 day-1) administration to rats begun 3 days before portal vein stenosis and then continued for 10 consecutive days, resulted in a significant decrease in both portal pressure (11.8 +/- 1.5 mmHg) and portal-systemic shunts (48 +/- 18%) which were measured 2 to 3 h after the final dose of propranolol (15.2 +/- 1.5 mmHg and 84 +/- 5%, respectively). These beneficial effects were also observed 18 to 24 h after the final dose of chronic propranolol. In rats given propranolol continuously for 5 days starting 5 days after portal vein stenosis, portal pressure (11.8 +/- 1.2 mmHg) was significantly lower than in the placebo group but portal-systemic shunts (76 +/- 14%) were not significantly different. In rats receiving a single dose of propranolol (75 mg/kg) 10 days after portal vein stenosis and measured 2 to 3 h after propranolol administration, portal pressure (12.8 +/- 1.0 mmHg) was significantly lower than in the placebo group. Portal-systemic shunts (72 +/- 17%), however, showed no significant difference from the placebo group. Similar values in portal pressure (13.3 +/- 1.2 mmHg) and portal-systemic shunts (83 +/- 21%) were also observed in rats 18 to 24 h after a single dose of propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors	H C Lin, O Soubrane, S Cailmail, D Lebrec
Journal	Journal of hepatology (J Hepatol) Vol. 13 Issue 2 Pg. 213-9 (Sep 1991) ISSN: 0168-8278 [Print] Netherlands
PMID	1744426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Propranolol
Topics	Animals Collateral Circulation (drug effects) Constriction, Pathologic (drug therapy) Hemodynamics (drug effects) Hypertension, Portal (drug therapy) Male Mesenteric Veins (drug effects) Portal Vein (drug effects) Propranolol (administration & dosage) Rats Rats, Inbred Strains Severity of Illness Index Splanchnic Circulation (drug effects) Time Factors

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