Interferon-alpha is effective for CD4(+), CCR4(-) mycosis fungoides.

Abstract

Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-gamma (IFN-gamma) for the treatment of CCR4(+) MF. In this report, we describe two cases of CD4(+), CCR4(-) MF successfully treated with IFN-alpha, but not IFN-gamma. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF.

• Authors: Taku Fujimura, Ryuhei Okuyama, Akiko Watabe, Akira Hashimoto, Hachiro Tagami, Setsuya Aiba
• Journal: International journal of dermatology (Int J Dermatol) Vol. 46 Issue 4 Pg. 435-8 (Apr 2007) ISSN: 0011-9059 [Print] England
• PMID: 17442093 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• CCR4 protein, human
• Interferon-alpha
• Receptors, CCR4
• Receptors, Chemokine

Topics

• Antineoplastic Agents (administration & dosage, therapeutic use)
• CD4-Positive T-Lymphocytes (metabolism)
• Diagnosis, Differential
• Erythema (etiology)
• Humans
• Injections, Subcutaneous
• Interferon-alpha (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Mycosis Fungoides (blood, complications, diagnosis, drug therapy, metabolism, pathology)
• Receptors, CCR4
• Receptors, Chemokine (metabolism)