Effects of multiple daily insulin injections on peripheral glucose disposal in Latin Americans with type 2 diabetes mellitus.

Abstract

OBJECTIVE:

To evaluate the effects of insulin in multiple daily injections (MDI) on peripheral glucose disposal in Latin American patients with type 2 diabetes.

METHODS AND RESULTS:

Ten Latin American patients (four men and six women) with type 2 diabetes between the ages of 32 and 45 years were evaluated. All women were premenopausal and had regular menstrual periods. A hyperinsulinemic-euglycemic clamp procedure was performed at baseline and was repeated approximately 2 years after insulin monotherapy on MDI was initiated. Both genders had comparable baseline anthropometric and laboratory features, including a mean body mass index > 30 kg/m2 and percent body fat > 30%. Baseline percent hemoglobin A1c (HbA1c%) was 9.5 +/- 1.5%, and post-intervention HbA1c% was 7.0 +/- 1.2%. The peripheral glucose disposal rate at baseline was 4.5 +/- 2.2 mg/kg/min fat-free mass and at postintervention was 3.6 +/- 2.3 mg/kg/min fat-free mass.

CONCLUSIONS:

Despite a significant improvement in glycemic control, MDI did not seem to increase the insulin-mediated glucose disposal rate. Underlying obesity and increased percent body fat may have been the most counteracting factors on the potential improvement in insulin sensitivity expected with insulin monotherapy.

• Authors: Larissa Avilés-Santa, Karin Salinas, Beverley Adams-Huet, Philip Raskin
• Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research (J Investig Med) Vol. 55 Issue 1 Pg. 11-7 (Jan 2007) ISSN: 1081-5589 [Print] England
• PMID: 17441407 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hemoglobins
• Hypoglycemic Agents
• Insulin
• hemoglobin A1c protein, human

Topics

• Adiposity (drug effects, ethnology)
• Adult
• Blood Glucose (metabolism)
• Body Mass Index
• Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
• Drug Administration Schedule
• Female
• Glucose Clamp Technique
• Glycated Hemoglobin
• Hemoglobins (analysis, drug effects)
• Humans
• Hypoglycemic Agents (administration & dosage)
• Injections
• Insulin (administration & dosage)
• Insulin Resistance (ethnology)
• Latin America (ethnology)
• Male
• Middle Aged
• Obesity (blood, complications, ethnology)
• Texas (epidemiology)