Abstract |
We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies summarizing information about 3375 MS cases and 2930 healthy controls. Two polymorphisms were of interest: the exon 1 +49 A/G polymorphism (in 18 studies) and the promoter-318 C/T polymorphism (in 10 studies). Using random-effects methods we found no evidence for association of the various contrasts of genotypes (or allele frequencies) with the disease. There was significant between-studies heterogeneity that could not be explained by the ethnicity of the populations studied or by other summary measures (gender, disease course, latitude). The major finding of the meta-analysis, apart from the lack of an overall association, consists of detecting a significant time trend of the OR for the contrast of GA versus GG+AA genotypes of the exon 1 +49 A/G polymorphism. In particular, using cumulative meta-analysis we found that the large number of conflicting results on the subject was triggered by the early appearance of a highly significant published result (a study that indicated a significant association of the genotype with the disease).
|
Authors | Pantelis G Bagos, Anthi C Karnaouri, Georgios K Nikolopoulos, Stavros J Hamodrakas |
Journal | Multiple sclerosis (Houndmills, Basingstoke, England)
(Mult Scler)
Vol. 13
Issue 2
Pg. 156-68
(Mar 2007)
ISSN: 1352-4585 [Print] England |
PMID | 17439880
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- Antigens, CD
- Antigens, Differentiation
- CTLA-4 Antigen
- CTLA4 protein, human
|
Topics |
- Antigens, CD
(genetics)
- Antigens, Differentiation
(genetics)
- CTLA-4 Antigen
- Genetic Predisposition to Disease
(epidemiology)
- Humans
- Multiple Sclerosis
(epidemiology, genetics)
- Polymorphism, Genetic
- Risk Factors
|