Abstract | AIMS: METHODS: RESULTS:
Pravastatin treatment significantly decreased plasma lipids in all patients (P < 0.001). Importantly, we showed an attenuated pravastatin pharmacodynamic effect on total cholesterol in patients with 521TC heterozygote genotype (from 5.52 +/- 0.51 mmol l(-1) to 4.70 +/- 0.35 mmol l(-1), % change -14.5 +/- 6.6%, N = 9) compared with 521TT homozygote genotype (from 5.47 +/- 1.15 mmol l(-1) to 4.21 +/- 0.89 mmol l(-1), % change -22.4 +/- 10.3%, N = 36) (mean +/- SD, P = 0.03, two-tailed test with alpha set at 5%). SLCO1B1 521T-->C functional polymorphism did not significantly influence pravastatin pharmacodynamics on other plasma lipids (P > 0.05). CONCLUSIONS: The 521T-->C polymorphism of SLCO1B1 appears to modulate significantly the total cholesterol-lowering efficacy of pravastatin in Chinese patients with CHD. Further studies are warranted to determine the extent to which SLCO1B1 genetic variation may contribute to resistance to pravastatin in Asian patients treated with standard doses of pravastatin.
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Authors | Wei Zhang, Bi-Lian Chen, Vural Ozdemir, Yi-Jing He, Gan Zhou, Dao-Di Peng, Sheng Deng, Qi-Ying Xie, Wei Xie, Lin-Yong Xu, Lian-Ci Wang, Lan Fan, An Wang, Hong-Hao Zhou |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 64
Issue 3
Pg. 346-52
(Sep 2007)
ISSN: 0306-5251 [Print] England |
PMID | 17439540
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Lipids
- Liver-Specific Organic Anion Transporter 1
- Organic Anion Transporters
- SLCO1B1 protein, human
- Cholesterol
- Pravastatin
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(pharmacology, therapeutic use)
- Asian People
- Cholesterol
(metabolism)
- Coronary Disease
(drug therapy)
- Female
- Genotype
- Humans
- Lipids
(blood)
- Liver-Specific Organic Anion Transporter 1
- Male
- Middle Aged
- Organic Anion Transporters
(genetics)
- Polymorphism, Genetic
- Pravastatin
(genetics, pharmacology, therapeutic use)
- Prospective Studies
- Treatment Outcome
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