Abstract | BACKGROUND:
Inulin and oligofructose promote selective growth of saccharolytic bacteria with low inflammatory potential. OBJECTIVE: DESIGN: Prospective, randomized, placebo controlled pilot trial. Eligible patients had been previously in remission with mesalazine as maintenance therapy or no drug, and presented with a relapse of mild to moderate activity. They were treated with mesalazine (3 g/day) and randomly allocated to receive either oligofructose-enriched inulin (12 g/day, p.o., n = 10) or placebo (12 g/day of maltodextrin, p.o., n = 9) for 2 week. Primary endpoint was the anti-inflammatory effect as determined by reduction of calprotectin and human DNA in faeces. RESULTS: Rachmilewitz score decreased in both groups, reaching statistical significance at day 14 (P < 0.05). Oligofructose-enriched inulin was well-tolerated and dyspeptic symptoms scale decreased significantly with active treatment but not with placebo. At day 7, an early significant reduction of calprotectin was observed in the group receiving oligofructose-enriched inulin (day 0: 4377 +/- 659 microg/g; day 7: 1033 +/- 393 microg/g, P < 0.05) but not in the placebo group (day 0: 5834 +/- 1563 microg/g; day 7: 4084 +/- 1395 microg/g, n.s.). Changes in faecal concentration of human DNA were not significant. CONCLUSION:
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Authors | F Casellas, N Borruel, A Torrejón, E Varela, M Antolin, F Guarner, J-R Malagelada |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 25
Issue 9
Pg. 1061-7
(May 01 2007)
ISSN: 0269-2813 [Print] England |
PMID | 17439507
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Gastrointestinal Agents
- Leukocyte L1 Antigen Complex
- Oligosaccharides
- oligofructose
- Inulin
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Topics |
- Adolescent
- Adult
- Aged
- Colitis, Ulcerative
(diet therapy, metabolism)
- Double-Blind Method
- Drug Combinations
- Feces
(chemistry)
- Female
- Gastrointestinal Agents
(administration & dosage)
- Humans
- Inulin
(administration & dosage)
- Leukocyte L1 Antigen Complex
(metabolism)
- Male
- Middle Aged
- Oligosaccharides
(administration & dosage)
- Pilot Projects
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