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[Anti-TNFalpha treatment of juvenile uveitis].

AbstractINTRODUCTION:
To present our experience with anti-TNFalpha treatment of juvenile idiopatic arthritis (JIA) associated uveitis.
MATERIALS AND METHODS:
All 11 children with severe uveitis were monitored between 2001 and 2005. Nine of the children had JIA and a set of twins had a rare hereditary granulomatous disease, Blau's syndrome. The patients were selected and the reason for starting anti-TNFalpha treatment was an insufficient response in the arthritis or uveitis to previous therapy.
RESULTS:
In all patients the anti-TNFalpha treatment reduced the activity of uveitis. The response to treatment was related to 1) visual acuity and 2) the reduction of systemic immune-suppressing agents. All 11 children are still on anti-TNFalpha treatment.
CONCLUSION:
Anti-TNFalpha was effective in treating uveitis in all 11 patients. In patients with active uveitis associated JIA not responding to corticosteroids and methotrexate and with declined vision the trend is to start anti-TNFalpha treatment early in the inflammatory disease to prevent long term complications to the eyes. The results indicate a superiority of infliximab over Eternacept in the treatment of uveitis.
AuthorsHans Callø Fledelius, Susan M Nielsen, Kamilla Rothe Nissen, Freddy Karup Pedersen, Marek Stanislaw Zak
JournalUgeskrift for laeger (Ugeskr Laeger) Vol. 169 Issue 14 Pg. 1309-12 (Apr 02 2007) ISSN: 1603-6824 [Electronic] Denmark
Vernacular TitleTumornekrosefaktor alpha-haemning som led i behandling af uveitis hos børn.
PMID17437693 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Infliximab
  • Etanercept
Topics
  • Anti-Inflammatory Agents (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Antibodies, Monoclonal (therapeutic use)
  • Antirheumatic Agents (therapeutic use)
  • Arthritis, Juvenile (drug therapy)
  • Child
  • Child, Preschool
  • Etanercept
  • Female
  • Granuloma (drug therapy, genetics)
  • Humans
  • Immunoglobulin G (therapeutic use)
  • Infliximab
  • Male
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Syndrome
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (adverse effects)
  • Uveitis (drug therapy, etiology)
  • Visual Acuity (drug effects)

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