Photodynamic therapy for cutaneous verrucous carcinoma.

Abstract

Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential. Photodynamic therapy relies on the selective intratumoral cell accumulation and photoactivation of a photosensitizer, leading to the generation of phototoxic compounds responsible for necrosis and apoptosis of the target cells. An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm(2) irradiations at 634-nm wavelength. The use of methyl-aminolevulinate-photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting.

• Authors: Arjen F Nikkels, Laurence Thirion, Pascale Quatresooz, Gérald E Piérard
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 57 Issue 3 Pg. 516-9 (Sep 2007) ISSN: 1097-6787 [Electronic] United States
• PMID: 17434646 (Publication Type: Case Reports, Journal Article)

Chemical References

• Photosensitizing Agents
• methyl 5-aminolevulinate
• Aminolevulinic Acid

Topics

• Aged, 80 and over
• Aminolevulinic Acid (administration & dosage, analogs & derivatives, therapeutic use)
• Carcinoma, Verrucous (drug therapy, pathology)
• Chronic Disease
• Drug Administration Schedule
• Humans
• Leg Dermatoses (drug therapy, pathology)
• Male
• Photochemotherapy
• Photosensitizing Agents (administration & dosage, therapeutic use)
• Skin Neoplasms (drug therapy, pathology)
• Treatment Outcome