[Apoptotic mechanisms induced in breast cancer cells by vinorelbine].

Abstract

Vinorelbine (VNB) is one of new semi-synthesized vinka alkaloids developed in France, of which anti-tumor activity is susceptible mainly to non-small cell lung cancer and breast cancer. Moreover, its clinical efficacy has been noted from single-agent therapy or combination therapy with taxanes. It is assumed that VNB selectively acts on tubulin which elaborates microtubules, strands the cells at G 1 phase and interferes with the mitosis. VNB has unique anti-tumor activity as an antimicrotubule agent and is expected to be available for treatment of multi-drug resistant tumors. In this report, we demonstrate that VNB, as an antimicrotubule agent, induces apoptosis in breast cancer cell line, MX-1 via a mitochondrial pathway.

• Authors: Hiroo Nakajima, Koichi Sakaguchi, Naruhiko Mizuta, Ikuya Fujiwara, Akemi Hayakawa, Junji Magae
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 4 Pg. 583-8 (Apr 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17431345 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Vinblastine
• Caspases
• Vinorelbine

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects, genetics)
• Breast Neoplasms (pathology)
• Caspases (metabolism)
• Cell Survival (drug effects)
• Female
• Humans
• Mitochondria (metabolism, physiology)
• Tumor Cells, Cultured
• Vinblastine (analogs & derivatives, pharmacology)
• Vinorelbine