Successful cardiac transplantation in Barth syndrome--single-centre experience of four patients.

Abstract

We describe four patients with Barth syndrome who have undergone successful orthotopic heart transplantation. Patients are one, seven, 12.5 and 14.7 yr post-transplantation. One episode of severe infection occurred. Renal dysfunction and coronary allograft vasculopathy do not appear accelerated over non-Barth patients. Despite withholding purine synthesis inhibitors, these patients have not demonstrated an increased rate of rejection.

• Authors: Jasveer Mangat, Tracy Lunnon-Wood, Philip Rees, Martin Elliott, Michael Burch
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 11 Issue 3 Pg. 327-31 (May 2007) ISSN: 1397-3142 [Print] Denmark
• PMID: 17430492 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Cardiomyopathies (etiology, surgery)
• Child
• Child, Preschool
• Genetic Diseases, X-Linked (complications)
• Heart Transplantation
• Humans
• Infant
• Male
• Metabolism, Inborn Errors (complications)
• Syndrome
• Treatment Outcome