Abstract | BACKGROUND: CASE REPORT: A 23-year-old male patient presented with continuous increase in height during the past 6 years due to a GH-secreting giant pituitary adenoma. Because of major intracranial extension and failure of octreotide treatment to shrink the tumour, the tumour was partially resected by a trans-frontal surgical approach. At immunohistochemistry, the tumour showed a marked expression of GH and a sparsely focal expression of prolactin. Somatostatin receptors (sst) 1-5 were not detected. Tumour tissue weakly expressed dopamine receptor type 2. The Gs alpha subunit was intact. Conversion from somatostatin analogue to pegvisomant normalized insulin-like-growth-factor-I ( IGF-I) levels and markedly improved glucose tolerance. CONCLUSION:
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Authors | K Müssig, B Gallwitz, J Honegger, C J Strasburger, M Bidlingmaier, F Machicao, A Bornemann, M B Ranke, H-U Häring, S Petersenn |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 115
Issue 3
Pg. 198-202
(Mar 2007)
ISSN: 0947-7349 [Print] Germany |
PMID | 17427111
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Human Growth Hormone
- pegvisomant
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Topics |
- Adenoma
(metabolism, surgery)
- Adult
- Gigantism
(drug therapy, etiology)
- Human Growth Hormone
(analogs & derivatives, metabolism, therapeutic use)
- Humans
- Magnetic Resonance Imaging
- Male
- Pituitary Neoplasms
(metabolism, surgery)
- Treatment Outcome
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