Abstract | OBJECTIVE: METHODS: TNF-alpha-308 and TNF-alpha-238 genotyping was conducted in a large, population-based cohort consisting of 886 beryllium workers (92 individuals with chronic beryllium disease, 64 who were beryllium sensitized, and 730 individuals without sensitization or disease). RESULTS: The odds of chronic beryllium disease in the presence of at least one TNF-alpha-308*02 or TNF-alpha-238*02 allele was not significant (OR=1.0; 95% CI=0.7, 1.7 and OR=0.8; 95% CI=0.4, 1.6). This was true regardless of whether a worker was homozygous or heterozygous for TNF-alpha-308*02 or TNF-alpha-238*02. Similarly, neither allele was associated with sensitization (P>0.05). CONCLUSIONS:
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Authors | Erin C McCanlies, Christine R Schuler, Kathleen Kreiss, Bonnie L Frye, James S Ensey, Ainsley Weston |
Journal | Journal of occupational and environmental medicine
(J Occup Environ Med)
Vol. 49
Issue 4
Pg. 446-52
(Apr 2007)
ISSN: 1076-2752 [Print] United States |
PMID | 17426528
(Publication Type: Journal Article)
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Chemical References |
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DPB1 antigen
- Tumor Necrosis Factor-alpha
- Beryllium
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Topics |
- Alleles
- Berylliosis
(genetics, immunology)
- Beryllium
(blood, immunology, toxicity)
- Chronic Disease
- Genotype
- HLA-DP Antigens
(genetics)
- HLA-DP beta-Chains
- Humans
- Hypersensitivity
(etiology, genetics)
- Lymphocyte Activation
- Occupational Exposure
(adverse effects)
- Polymorphism, Genetic
- Risk Factors
- Sequence Analysis, Protein
- Tumor Necrosis Factor-alpha
(chemistry, genetics)
- United States
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