TSH-secreting
adenoma is a rare
pituitary adenoma, and the expression levels of the specific subtypes of
somatostatin receptors (sstr) mRNAs have remained obscure. To determine the quantitative expression of the sstr1-5 mRNAs in TSH-secreting
adenomas that may be related to the efficacy of treatment with a
somatostatin analogue, expression of the sstr1-5 mRNAs was examined and compared in TSH-secreting
adenomas and other
pituitary adenomas. The
pituitary adenomas were obtained at transsphenoidal surgery from 4 cases of TSH-secreting
adenoma, including 1 patient showing a significant shrinkage of the
tumor size after only 10 days of
octreotide treatment, 2 patients without
tumor size reduction and 1 patient without treatment, and 5 GH-secreting
adenomas, 6
prolactinomas, 5 nonfunctioning
adenomas, 4
ACTH-secreting
adenomas and normal pituitaries at autopsy from 4 normal subjects. In comparison to the normal pituitary,
sstr2A>
sstr1>sstr5>sstr3 mRNAs were expressed in the TSH-secreting
adenomas examined. No expression of sstr2B or sstr4
mRNA was observed. The expression level of sstr2
mRNA was significantly higher than those in normal pituitary,
prolactinomas,
ACTH-secreting and nonfunctioning
pituitary adenomas. The patient with marked shrinkage of the
tumor showed the highest expression of both sstr2 and sstr5 mRNAs among all the cases of
pituitary adenoma. A TSH-secreting
tumor without shrinkage showed a similar expression level of sstr2
mRNA. These findings demonstrated that TSH-secreting
adenomas express
sstr1, 2A, 3 and 5 mRNAs, predominantly
sstr2A, and in addition to the expression of sstr2
mRNA, the expression level of sstr5
mRNA may be
a factor affecting the
tumor shrinkage by
somatostatin analogues against TSH-secreting
adenomas.