Abstract | OBJECTIVES: STUDY DESIGN AND SETTING: Four weeks following surgery, 54 rats (18 of which received a cochleostomy alone, 18 of which received a cochleostomy and acute cochlear implantation using standard surgical techniques, and 18 of which received a cochlear implant) were infected with Streptococcus pneumoniae via three different routes of bacterial inoculation (middle ear, inner ear, and intraperitoneal) to represent all potential routes of bacterial infection from the upper respiratory tract to the meninges. RESULTS: CONCLUSION: SIGNIFICANCE:
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Authors | Benjamin P C Wei, Robert K Shepherd, Roy M Robins-Browne, Graeme M Clark, Stephen J O'Leary |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 136
Issue 4
Pg. 589-96
(Apr 2007)
ISSN: 0194-5998 [Print] England |
PMID | 17418257
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Cochlear Implantation
- Cochlear Implants
(adverse effects)
- Meningitis, Pneumococcal
(microbiology)
- Prosthesis-Related Infections
(microbiology)
- Rats
- Rats, Wistar
- Risk Factors
- Streptococcus pneumoniae
(pathogenicity)
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