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Holmes tremor secondary to brainstem hemorrhage responsive to levodopa: report of 2 cases.

Abstract
We report 2 patients who presented a brainstem hemorrhage and who, after 1 and 6 months, respectively, developed a 4-Hz postural and resting tremor consistent with Holmes tremor, which severely interfered with the activities of daily living. In both cases, levodopa dramatically improved the tremor. Pharmacological treatment of this condition is usually disappointing, and surgical procedures are commonly required for severe cases. Our patients, together with 13 others gleaned from the literature, suggest that in cases of Holmes tremor secondary to brainstem hemorrhage, levodopa can be a useful treatment, and it should be tested before considering invasive therapies.
AuthorsGabriela B Raina, Miriam Velez, Manuel Fernandez Pardal, Federico Micheli
JournalClinical neuropharmacology (Clin Neuropharmacol) 2007 Mar-Apr Vol. 30 Issue 2 Pg. 95-100 ISSN: 0362-5664 [Print] United States
PMID17414941 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiparkinson Agents
  • Levodopa
Topics
  • Adult
  • Antiparkinson Agents (therapeutic use)
  • Brain Stem (pathology)
  • Electromyography (methods)
  • Female
  • Humans
  • Intracranial Hemorrhages (complications, pathology)
  • Levodopa (therapeutic use)
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Review Literature as Topic
  • Time Factors
  • Tremor (drug therapy, etiology)

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