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Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease.

AbstractBACKGROUND:
The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing due to its prevalence in obesity, diabetes, and insulin-resistance syndrome. The best treatment protocol for NAFLD has not been determined. However, there is evidence that exercise and nutritional intervention can improve and prevent it. The aim of the present study was to evaluate the dietary and metabolic profiles of obese adolescents with NAFLD who participated in a multidisciplinary program.
PATIENTS AND METHODS:
We studied 43 adolescents ages 15 to 19 years (17.18 +/- 1.66 years) with a body mass index (BMI) > or = 30, consisting of 30 patients without NAFLD (BMI = 35.80 +/- 3.44 kg/m2) and 13 with NAFLD (BMI = 33.47 +/- 2.34 kg/m2). The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic aminotransferase levels, and lipid profiles. Insulin resistance was measured by homeostasis model assessment insulin-resistance index (HOMA-IR). The analyses of baseline and postintervention food intake were made by a 3-day inquiry.
RESULTS:
At baseline conditions, the patients with NAFLD showed significant differences in body mass, BMI, and visceral and subcutaneous fat. Glucose and visceral and subcutaneous fat presented a significant reduction after treatment in patients with NAFLD. Analyzing the food intake, at baseline we observed a positive correlation between the visceral obesity and lipid consumption only in patients with NAFLD. We also observed significant decrease in energy and cholesterol consumption in patients with NAFLD after the multidisciplinary therapy.
CONCLUSIONS:
The intervention promoted a decrease in the prevalence of NAFLD, a significant decrease in visceral obesity, and improved HOMA-IR, glycemia, and serum lipid levels that are risk factors for NAFLD. In summary, the multidisciplinary program is essential in the treatment and prevention of NAFLD.
AuthorsAline de Piano, Wagner L Prado, Danielle A Caranti, Kãli O Siqueira, Sérgio G Stella, Mara Lofrano, Lian Tock, Dejaldo M J Cristofalo, Henrique Lederman, Sérgio Tufik, Marco Túlio de Mello, Ana R Dâmaso
JournalJournal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 44 Issue 4 Pg. 446-52 (Apr 2007) ISSN: 1536-4801 [Electronic] United States
PMID17414142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dietary Fats
Topics
  • Adolescent
  • Adult
  • Body Fat Distribution
  • Dietary Fats
  • Energy Intake
  • Fatty Liver (blood, diagnostic imaging, etiology)
  • Female
  • Humans
  • Insulin Resistance
  • Male
  • Nutritional Status
  • Obesity (complications, therapy)
  • Risk Factors
  • Ultrasonography

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