Abstract | OBJECTIVE: Fluid resuscitation to improve delivery of oxygen to vital organs is a principal clinical intervention for septic patients. We previously reported that albumin resuscitation in rat endotoxemia improved contractility in isolated cardiomyocytes, but whether this effect occurs in vivo is unknown. We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo. DESIGN: Randomized, controlled, prospective animal study. SETTING: University animal laboratory. SUBJECTS: Male Sprague-Dawley rats (250-350 g). INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Chiho Tokunaga, Ryon M Bateman, John Boyd, Yingjin Wang, James A Russell, Keith R Walley |
Journal | Critical care medicine
(Crit Care Med)
Vol. 35
Issue 5
Pg. 1341-7
(May 2007)
ISSN: 0090-3493 [Print] United States |
PMID | 17414087
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Albumins
- Endotoxins
- Hypoxia-Inducible Factor 1, alpha Subunit
- Lipopolysaccharides
- RNA, Messenger
- endotoxin, Escherichia coli
- Oxygen
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Topics |
- Albumins
(pharmacology, therapeutic use)
- Animals
- Disease Models, Animal
- Endotoxemia
(therapy)
- Endotoxins
- Escherichia coli
- Fluid Therapy
(methods)
- Hypoxia
(physiopathology)
- Hypoxia-Inducible Factor 1, alpha Subunit
(metabolism)
- Lipopolysaccharides
- Male
- Myocardial Contraction
(drug effects)
- Myocardium
(metabolism)
- Oxygen
(metabolism)
- RNA, Messenger
(metabolism)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Ventricular Function
(drug effects)
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