Abstract |
Metastatic lung carcinomas with clear cell morphology can be confused with primary ovarian clear cell carcinomas. We performed immunohistochemical stains in 14 cases of non-small cell lung carcinomas with clear cell features and 14 cases of ovarian clear cell carcinomas using a panel of markers, including thyroid transcription factor 1 (TTF-1), carcinoembryonic antigen (CEA), Wilms tumor gene 1, octamer-binding transcription factor 4 (OCT-4), cancer antigen 125 (CA-125), estrogen receptor, and progesterone receptor. Among non-small cell lung carcinomas with clear cell features, 87.5% of adenocarcinomas (or 50% overall frequency in lung carcinomas) were positive for TTF-1, whereas none of the ovarian clear cell carcinomas were positive (P = 0.002). All 14 ovarian clear cell carcinomas stained for CA-125 as compared with 1 non-small cell lung carcinoma (P < 0.001). On the other hand, 85% of non-small cell lung carcinomas stained for CEA, whereas none of the ovarian clear cell carcinomas did (P < 0.001). Interestingly, 4 ovarian clear cell carcinomas (28%) showed positive staining for the germ cell marker OCT-4. Either lung or ovarian carcinomas stained for Wilms tumor gene 1, estrogen receptor, or progesterone receptor very infrequently; and the difference between the 2 groups was not statistically significant. Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features.
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Authors | Nicole R Howell, Wenxin Zheng, Liang Cheng, Carmen Tornos, Philip Kane, Michael Pearl, Eva Chalas, Sharon X Liang |
Journal | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
(Int J Gynecol Pathol)
Vol. 26
Issue 2
Pg. 134-40
(Apr 2007)
ISSN: 0277-1691 [Print] United States |
PMID | 17413979
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- Carcinoembryonic Antigen
- NKX2-1 protein, human
- Nuclear Proteins
- Octamer Transcription Factor-3
- Thyroid Nuclear Factor 1
- Transcription Factors
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Topics |
- Adenocarcinoma, Clear Cell
(diagnosis, metabolism, secondary)
- Adult
- Biomarkers, Tumor
(metabolism)
- CA-125 Antigen
(genetics, metabolism)
- Carcinoembryonic Antigen
(genetics, metabolism)
- Carcinoma, Non-Small-Cell Lung
(diagnosis, metabolism, pathology)
- Diagnosis, Differential
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
(diagnosis, metabolism, pathology)
- Nuclear Proteins
(genetics, metabolism)
- Octamer Transcription Factor-3
(genetics, metabolism)
- Ovarian Neoplasms
(diagnosis, metabolism, secondary)
- Thyroid Nuclear Factor 1
- Transcription Factors
(genetics, metabolism)
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