The effect of a silybin-vitamin e-phospholipid complex on nonalcoholic fatty liver disease: a pilot study.
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| Abstract |
Oxidative stress leads to chronic liver damage. Silybin has been conjugated with vitamin E and phospholipids to improve its antioxidant activity. Eighty-five patients were divided into 2 groups: those affected by nonalcoholic fatty liver disease (group A) and those with HCV-related chronic hepatitis associated with nonalcoholic fatty liver disease (group B), nonresponders to treatment. The treatment consisted of silybin/vitamin E/phospholipids. After treatment, group A showed a significant reduction in ultrasonographic scores for liver steatosis. Liver enzyme levels, hyperinsulinemia, and indexes of liver fibrosis showed an improvement in treated individuals. A significant correlation among indexes of fibrosis, body mass index, insulinemia, plasma levels of transforming growth factor-beta, tumor necrosis factor-alpha, degree of steatosis, and gamma-glutamyl transpeptidase was observed. Our data suggest that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage.
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| Authors | Carmela Loguercio, Alessandro Federico, Marco Trappoliere, Concetta Tuccillo, Ilario de Sio, Agnese Di Leva, Marco Niosi, Mauro Valeriano D'Auria, Rita Capasso, Camillo Del Vecchio Blanco, Real Sud Group |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 52 Issue 9 Pg. 2387-95 (Sep 2007) ISSN: 0163-2116 [Print] United States |
| PMID | 17410454 (Publication Type: Journal Article) |
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