Abstract | PURPOSE: METHODS AND MATERIALS: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy(E)), with 2.5-Gy(E) once-daily fractionations. RESULTS: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. CONCLUSIONS: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study.
|
Authors | Hideki Nishimura, Takashi Ogino, Mitsuhiko Kawashima, Keiji Nihei, Satoko Arahira, Masakatsu Onozawa, Shoichi Katsuta, Teiji Nishio |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 68
Issue 3
Pg. 758-62
(Jul 01 2007)
ISSN: 0360-3016 [Print] United States |
PMID | 17398027
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Disease-Free Survival
- Esthesioneuroblastoma, Olfactory
(diagnosis, radiotherapy)
- Female
- Humans
- Male
- Middle Aged
- Nasal Cavity
- Neoplasm Recurrence, Local
(diagnosis, prevention & control)
- Nose Neoplasms
(diagnosis, radiotherapy)
- Proton Therapy
- Retrospective Studies
|