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The price of seizure control: dynorphins in interictal and postictal psychosis.

Abstract
Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits anticonvulsant and psychotomimetic effects. In view of this background, here we introduce the hypothesis that epilepsy-related psychoses may partially result from excessive hippocampal dynorphin release and kappa opioid receptor overstimulation aimed at seizure control.
AuthorsMarco Bortolato, Marylou V Solbrig
JournalPsychiatry research (Psychiatry Res) Vol. 151 Issue 1-2 Pg. 139-43 (May 30 2007) ISSN: 0165-1781 [Print] Ireland
PMID17395273 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Anticonvulsants
  • Receptors, Opioid, kappa
  • Dynorphins
Topics
  • Animals
  • Anticonvulsants (metabolism)
  • Dynorphins (metabolism)
  • Epilepsy, Temporal Lobe (complications, physiopathology)
  • Hippocampus (physiopathology)
  • Humans
  • Kindling, Neurologic (physiology)
  • Psychotic Disorders (physiopathology)
  • Receptors, Opioid, kappa (physiology)

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