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Hamartomatous proliferations of odontogenic epithelium within the jaws: a potential histogenetic source of intraosseous epithelial odontogenic tumors.

AbstractBACKGROUND:
The jawbone is replete with a vestige of odontogenesis. The overall consensus is that intraosseous remnants of the enamel organ and dental lamina are the only histogenetic option for central epithelial odontogenic tumors. Curiously, incipient tumors or possible precursor conditions of residual odontogenic epithelium have rarely been reported in the literature.
METHODS:
We microscopically evaluated 39,660 biopsy samples to determine the presence of a tumor-like odontogenic epithelial nodule in the maxilla and mandible.
RESULTS:
Seven intraosseous specimens that associated with a focal proliferation of odontogenic epithelium were retrieved. Six hamartomatous processes showed four different morphologic patterns comparable with the tumor nests comprising ameloblastoma (n = 1), squamous odontogenic tumor (n=1), calcifying epithelial odontogenic tumor (n=2) and calcifying cystic odontogenic tumor (n=2). Among six lesions, four were the intrafollicular development. The remaining case of interest was multiple hyperplastic clear rests of Malassez in association with an impacted tooth.
CONCLUSION:
Although it is impossible to predict the fate of these microscopic structures of hamartomatous character, the present case series indicates that any of the dormant embryonic residues of odontogenic epithelium can return to an active state, capable of non-reactive, probably neoplastic proliferation of pathological significance.
AuthorsF Ide, K Obara, H Yamada, K Mishima, I Saito, N Horie, T Shimoyama, K Kusama
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 36 Issue 4 Pg. 229-35 (Apr 2007) ISSN: 0904-2512 [Print] Denmark
PMID17391301 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Ameloblastoma (etiology)
  • Child
  • Epithelium (embryology)
  • Hamartoma (complications)
  • Humans
  • Jaw Diseases (complications)
  • Jaw Neoplasms (etiology)
  • Male
  • Middle Aged
  • Neoplasms, Squamous Cell (etiology)
  • Odontogenic Tumors (etiology)
  • Tooth Germ (cytology)

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