Antibody responses to pneumococcal polysaccharide vaccine in Taiwanese patients with chronic obstructive pulmonary disease.

Abstract

BACKGROUND/PURPOSE:

A study was undertaken to assess the antibody responses to a 23-valent pneumococcal polysaccharide vaccine and clinical outcome in Taiwanese patients with chronic obstructive pulmonary disease (COPD).

METHODS:

From January to December 1999, 80 Taiwanese patients with COPD were enrolled. Each patient received a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23). Specific IgG antibodies to pneumococcal capsular antigens of serotypes 4, 6B, 7F, 9V, 14, 18C, 19F, and 23F were measured before vaccination, and 6 weeks and 52 weeks after vaccination.

RESULTS:

Detectable prevaccination IgG antibody (> 1 microg/mL) was found in the range of 27.5% of patients for serotype 7F to 96.2% for serotype 14. Antibody concentrations in prevaccination sera were not different between middle-aged (< 65 years old) and elderly patients (> or = 65 years old). The percentage of elderly patients with postvaccination antibody concentration > 2 -fold higher than that prior to vaccination ranged from 84% for serotype 18C to 90% for serotypes 7F, 9V, and 19F. The change in antibody level (fold and absolute increases) postvaccination was not significantly different among the different age groups.

CONCLUSION:

Taiwanese elderly adults with COPD, even in advanced age, can mount a significant antibody response to pneumococcal polysaccharide vaccine. This study may support the existing recommendation that pneumococcal vaccine be offered to persons > or = 65 years old with COPD.

• Authors: Chih-Cheng Lai, Li-Na Lee, Chong-Jen Yu, Po-Ren Hsueh, Pan-Chyr Yang, Sow-Hsong Kuo, Kwen-Tay Luh
• Journal: Journal of the Formosan Medical Association = Taiwan yi zhi (J Formos Med Assoc) Vol. 106 Issue 3 Pg. 196-203 (Mar 2007) ISSN: 0929-6646 [Print] Singapore
• PMID: 17389163 (Publication Type: Journal Article)

Chemical References

• 23-valent pneumococcal capsular polysaccharide vaccine
• Antibodies, Bacterial
• Immunoglobulin G
• Pneumococcal Vaccines

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Antibodies, Bacterial (blood)
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Pneumococcal Vaccines (immunology)
• Pulmonary Disease, Chronic Obstructive (immunology)
• Streptococcus pneumoniae (immunology)
• Vaccination