Abstract | BACKGROUND/OBJECTIVE: METHODS: Fourteen individuals participated (7 with tetraplegia and 7 controls). Subjects visited the laboratory twice for placebo on day 1 and L-NAME (1 mg/kg) on day 2; both were infused intravenously over 60 minutes. Blood pressure was monitored for 3 hours after infusion at the brachial artery using a standard manual cuff. RESULTS: Mean arterial pressure (MAP) was lower at baseline (P < 0.05) and after placebo administration (P < 0.0001) in the tetraplegia group compared with the control group. L-NAME increased MAP in both groups; however, the relative increase was greater in the tetraplegia group compared with the control group, such that group differences for MAP were eliminated. Supine MAP was normalized with L-NAME, and there was an increased sensitivity to NOS inhibition in the group with tetraplegia. CONCLUSIONS: These findings indicate that blood pressure dysregulation in persons with tetraplegia may reflect increased vascular NO and suggest a novel treatment of hypotension using NOS inhibition in this population.
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Authors | Jill M Wecht, Joseph P Weir, AnnMarie H Krothe, Ann M Spungen, William A Bauman |
Journal | The journal of spinal cord medicine
(J Spinal Cord Med)
Vol. 30
Issue 1
Pg. 5-9
( 2007)
ISSN: 1079-0268 [Print] England |
PMID | 17385265
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Enzyme Inhibitors
- Nitric Oxide
- Nitric Oxide Synthase
- NG-Nitroarginine Methyl Ester
|
Topics |
- Adult
- Blood Pressure
(drug effects)
- Electrocardiography
(drug effects)
- Enzyme Inhibitors
(adverse effects, therapeutic use)
- Heart Rate
(drug effects)
- Humans
- Hypotension, Orthostatic
(drug therapy)
- Infusions, Intravenous
- Male
- Middle Aged
- NG-Nitroarginine Methyl Ester
(adverse effects, therapeutic use)
- Nitric Oxide
(blood)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Quadriplegia
(drug therapy)
- Spinal Cord Injuries
(drug therapy)
- Supine Position
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