Abstract | OBJECTIVE: METHODS: Ascending thoracic aortic aneurysm samples taken from patients with bicuspid aortic valve (n = 53) and patients with tricuspid aortic valve (n = 46) were assessed for representative subtypes of all matrix metalloproteinase classes and all 4 known tissue inhibitors of metalloproteinases. Levels were compared [optical density units, median (interquartile range)] both to reference control ascending aortic samples (n = 26) and within each valve group by aneurysm diameter (< or =3.9 cm, 4.0-5.9 cm and > or =6.0 cm). RESULTS: CONCLUSIONS:
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Authors | John S Ikonomidis, Jeffery A Jones, John R Barbour, Robert E Stroud, Leslie L Clark, Brooke S Kaplan, Ahmed Zeeshan, Joseph E Bavaria, Joseph H Gorman 3rd, Francis G Spinale, Robert C Gorman |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 133
Issue 4
Pg. 1028-36
(Apr 2007)
ISSN: 1097-685X [Electronic] United States |
PMID | 17382648
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Tissue Inhibitor of Metalloproteinases
- Matrix Metalloproteinases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aortic Aneurysm
(complications, metabolism, surgery)
- Aortic Valve
- Cardiovascular Surgical Procedures
- Female
- Heart Valve Diseases
(complications, physiopathology, surgery)
- Humans
- Male
- Matrix Metalloproteinases
(biosynthesis)
- Middle Aged
- Tissue Inhibitor of Metalloproteinases
(biosynthesis)
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