A comparison of the influence of a high-fat diet enriched in monounsaturated fatty acids and conventional diet on weight loss and metabolic parameters in obese non-diabetic and Type 2 diabetic patients.

Abstract

AIMS:

The aim of our study was to compare the influence of a hypocaloric, high-fat diet enriched with MUFA (M) and conventional diet (C) on weight loss and metabolic parameters in obese non-diabetic and obese Type 2 diabetic subjects over a 3-month period. It was our hypothesis that the enriched diet would be more effective in decreasing blood glucose and glycated haemoglobin (HbA(1c)) than the control diet.

METHODS:

Twenty-seven Type 2 diabetic patients (54.5 +/- 3.5 years; DM), treated with diet or oral glucose-lowering agents, and 31 obese non-diabetic subjects (53.6 +/- 3.5 years; OB) were randomized to M or C. Individual calculations of energy requirements were based on the formula: [resting energy expenditure (REE) x 1.5] - 600 kcal. Subjects were assessed by a dietitian every 2 weeks and by a physician every month. Statistical analyses were carried out between the four groups--DM/M, DM/C, OB/M and OB/C--using pair Student's test and anova.

RESULTS:

After 3 months, body weight, waist-hip ratio, total body fat, levels of C-peptide, triglycerides and homeostasis model assessment (HOMA) decreased in all four groups (P < 0.01). However, fasting blood glucose and HbA(1c) decreased (P < 0.01) and high-density lipoprotein cholesterol increased significantly only in the DM/M group (P < 0.05). In general, M was well tolerated.

CONCLUSIONS:

Individualized M and C diets were successful in improving metabolic and anthropometric parameters in both the obese non-diabetic and the Type 2 diabetic subjects. Although the superiority of the higher fat diet did not reach statistical significance, the decline in blood glucose and HbA(1c) in the Type 2 diabetic group on M was encouraging.

• Authors: L Brunerova, V Smejkalova, J Potockova, M Andel
• Journal: Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 24 Issue 5 Pg. 533-40 (May 2007) ISSN: 0742-3071 [Print] England
• PMID: 17381504 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Dietary Fats
• Fatty Acids, Monounsaturated

Topics

• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (diet therapy)
• Diet, Diabetic
• Dietary Fats
• Fatty Acids, Monounsaturated
• Humans
• Middle Aged
• Obesity (diet therapy)
• Weight Loss