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Cheyne-Stokes respiration in patients with heart failure: ominous sign or innocent bystander?

Abstract
Cheyne-Stokes respiration (CSR) during the day and at night is common in patients with severe heart failure. CSR harms the failing heart through recurrent sympathetic overstimulation caused by sleep disturbances and intermittent hypoxia brought about by apnoea and hypopnoea. CSR impairs patients' quality of life and wakefulness, and probably also increases cardiac mortality in patients with heart failure. Thus, CSR should be actively sought in patients with a left ventricular ejection fraction <40%. When CSR persists despite optimal drug therapy for heart failure, non-invasive ventilation, particularly as adaptive servoventilation, and cardiac resynchronisation therapy are currently the most promising treatment options.
AuthorsThomas Brack
JournalSwiss medical weekly (Swiss Med Wkly) Vol. 137 Issue 9-10 Pg. 133-8 (Mar 10 2007) ISSN: 1424-7860 [Print] Switzerland
PMID17370153 (Publication Type: Journal Article, Review)
Topics
  • Cheyne-Stokes Respiration (physiopathology)
  • Heart Failure (physiopathology)
  • Humans
  • Quality of Life
  • Quality-Adjusted Life Years
  • Sleep Apnea, Central (physiopathology)
  • Wakefulness

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