[Clinical application of brain hypothermia therapy for acute brain insults].

Brain hypothermia therapy has been expected to lead to good neurological outcome in acute brain insults. There are a few positive results which have been proven by multicenter randomized clinical trials (RCT) in the cardiopulmonary arrest (CPA) in patients with ventricular fibrillation. Among these clinical trials, early application of hypothermia, maintenance of cerebral blood flow during hypothermia therapy and prevention of quick rewarming are pointed out to result in good outcome from clinical experiences. For brain hypothermia therapy to become an effective method for acute brain insults, indications, brain oriented intensive cares and biomarkers for the therapy must be established. RCT in acute brain insults beside CPA victims are needed in the near future.
AuthorsTadashi Kaneko, Tsuyoshi Maekawa
JournalMasui. The Japanese journal of anesthesiology (Masui) Vol. 56 Issue 3 Pg. 280-4 (Mar 2007) ISSN: 0021-4892 [Print] Japan
PMID17366915 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Droperidol
  • Acute Disease
  • Brain Injuries (therapy)
  • Cardiopulmonary Resuscitation (methods)
  • Critical Care (methods)
  • Droperidol (administration & dosage)
  • Evidence-Based Medicine
  • Heart Arrest (therapy)
  • Humans
  • Hypothermia, Induced (adverse effects, methods)
  • Neuroleptanalgesia (adverse effects, methods)
  • Randomized Controlled Trials as Topic
  • Ventricular Fibrillation (therapy)

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