Abstract | BACKGROUND: METHODS: In 2002-2005, 67 pregnancies of 66 buprenorphine users were followed prospectively in an outpatient multidisciplinary antenatal setting by an obstetrician, a midwife, a psychiatric nurse and a social worker. Decreasing doses or even abstinence from buprenorphine was encouraged. Outcome measures were daily buprenorphine dose, fetal growth, gestational age at birth, mode of delivery, birth weight, Apgar scores, umbilical pH values, and occurrence of neonatal abstinence syndrome [ NAS]. National statistics were used as reference values. RESULTS: The daily dose of buprenorphine decreased by 2.3 mg (median, range increase of 8 mg to decrease of 24 mg). There were no more incidences of premature birth, cesarean section, low Apgar scores (< or = 6) or umbilical artery pH <7.05 at birth than in the national register, despite the lower birth weight. A total of 91% of the infants needed treatment in a neonatal care unit, 76% had NAS, and 57% needed morphine replacement therapy. Seven infants were taken into care directly from the maternity hospital. Two sudden infant deaths occurred later. CONCLUSIONS:
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Authors | Hanna Kahila, Terhi Saisto, Satu Kivitie-Kallio, Maija Haukkamaa, Erja Halmesmäki |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 86
Issue 2
Pg. 185-90
( 2007)
ISSN: 0001-6349 [Print] United States |
PMID | 17364281
(Publication Type: Journal Article)
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Chemical References |
- Hepatitis C Antibodies
- Narcotics
- Buprenorphine
- Morphine
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Topics |
- Birth Weight
(drug effects)
- Buprenorphine
(administration & dosage, adverse effects)
- Female
- Hepatitis C Antibodies
(blood)
- Humans
- Infant, Newborn
- Morphine
(therapeutic use)
- Narcotics
(administration & dosage, adverse effects)
- Neonatal Abstinence Syndrome
(drug therapy, etiology)
- Opioid-Related Disorders
(rehabilitation)
- Pregnancy
- Pregnancy Complications
(rehabilitation)
- Pregnancy Outcome
- Prospective Studies
- Smoking
(epidemiology)
- Sudden Infant Death
(epidemiology)
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