Abstract |
The effects of NG-nitro-L-arginine (NNA; an inhibitor of the oxidative L-arginine pathway) on convulsions induced by cyanide were investigated in mice. NNA prevented cyanide-induced convulsions in a dose-dependent manner. Furthermore, the inhibitory effect against convulsions induced by cyanide with NNA was abolished by pretreatment of L-arginine. However, NNA did not change blood cyanide levels in mice 5 min after injection of potassium cyanide. Since NNA prevents against oxidative L-arginine pathway-dependent guanylate cyclase activation in intact cells, it was suggested that the protection against cyanide-induced convulsions with NNA may be due to the inhibition of guanylate cyclase. In support, methylene blue, an inhibitor of guanylate cyclase, elicited a similar inhibition against convulsions induced by cyanide.
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Authors | H Yamamoto |
Journal | Toxicology
(Toxicology)
Vol. 71
Issue 3
Pg. 277-83
( 1992)
ISSN: 0300-483X [Print] Ireland |
PMID | 1736419
(Publication Type: Journal Article)
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Chemical References |
- Nitroarginine
- Arginine
- Potassium Cyanide
- Methylene Blue
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Topics |
- Animals
- Arginine
(analogs & derivatives, pharmacology)
- Male
- Methylene Blue
(therapeutic use)
- Mice
- Nitroarginine
- Potassium Cyanide
(toxicity)
- Seizures
(chemically induced, prevention & control)
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