Outcome of infants from mothers with anti-SSA/Ro antibodies.

Abstract

OBJECTIVE:

To evaluate the incidence of electrocardiographic and laboratory abnormalities in neonates born from mothers with connective tissue disease and positive for anti-SSA/Ro antibodies.

STUDY DESIGN:

Electrocardiogram, blood cell counts, liver and renal function tests prospectively obtained from 51 infants born from anti-SSA/Ro-positive mothers with connective tissue disease were compared with those obtained from 50 control infants born from mothers with anti-extractable nuclear antigen (ENA)-negative connective tissue disease. One infant with congenital complete heart block was excluded from analysis.

RESULTS:

No infant showed sinus bradycardia. A first-degree atrioventricular block at birth was observed in five study group and no control group infants, P=0.023. Atrioventricular blocks spontaneously reverted or remained stable during the first year of life. Mean corrected QT value of infants born from anti-SSA/Ro-positive mothers was slightly prolonged as compared with the control group (0.404+/-0.03 s vs 0.395+/-0.02 s; P=0.060).

CONCLUSIONS:

Infants exposed to anti-SSA/Ro antibodies had a significantly higher prevalence of first-degree atrioventricular block. At variance with previous studies, we observed a low frequency of hematologic abnormalities and no cases of hepatobiliary disease.

• Authors: M Motta, C Rodriguez-Perez, A Tincani, A Lojacono, G Chirico
• Journal: Journal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 27 Issue 5 Pg. 278-83 (May 2007) ISSN: 0743-8346 [Print] United States
• PMID: 17363909 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antinuclear
• SS-A antibodies

Topics

• Antibodies, Antinuclear (blood)
• Blood Cell Count
• Connective Tissue Diseases (diagnosis, immunology)
• Electrocardiography
• Female
• Follow-Up Studies
• Heart Block (diagnosis, immunology)
• Humans
• Infant
• Infant, Newborn
• Infant, Newborn, Diseases (diagnosis, immunology)
• Liver Function Tests
• Long QT Syndrome (diagnosis, immunology)
• Male
• Pregnancy
• Pregnancy Complications, Hematologic (diagnosis, immunology)
• Prospective Studies
• Remission, Spontaneous