Abstract | PURPOSE: EXPERIMENTAL DESIGN: Mice bearing syngeneic ovarian or mammary carcinomas were treated with nab-paclitaxel, radiation, or combination of both. Nab-paclitaxel was administered at 90 mg/kg, 1.5 times the maximum tolerated dose for solvent-based paclitaxel. End points were antitumor efficacy (growth delay, radiocurability, and cellular effects) and normal tissue toxicity (gut and skin). RESULTS:
Nab-paclitaxel showed single- agent antitumor efficacy against both tumor types and acted as a radiosensitizer. Combined with radiation, nab-paclitaxel produced supra-additive effects when given before radiation. Nab-paclitaxel significantly increased radiocurability by reducing the dose yielding 50% tumor cure (TCD(50)) from 54.3 to 35.2 Gy. Tumor histology following nab-paclitaxel treatment was characterized by pronounced necrotic and apoptotic cell death and mitotic arrest. Nab-paclitaxel did not increase normal tissue radioresponse. CONCLUSIONS:
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Authors | Nicole Wiedenmann, David Valdecanas, Nancy Hunter, Stephen Hyde, Thomas A Buchholz, Luka Milas, Kathryn A Mason |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 13
Issue 6
Pg. 1868-74
(Mar 15 2007)
ISSN: 1078-0432 [Print] United States |
PMID | 17363543
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- 130-nm albumin-bound paclitaxel
- Albumins
- Antineoplastic Agents
- Radiation-Sensitizing Agents
- Paclitaxel
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Topics |
- Adenocarcinoma
(pathology, radiotherapy)
- Albumins
(chemistry, therapeutic use)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Combined Modality Therapy
- Female
- Mammary Neoplasms, Experimental
(pathology, radiotherapy)
- Mice
- Mice, Inbred C3H
- Neoplasm Transplantation
- Ovarian Neoplasms
(pathology, radiotherapy)
- Paclitaxel
(chemistry, therapeutic use)
- Radiation Dosage
- Radiation-Sensitizing Agents
(therapeutic use)
- Tumor Burden
(drug effects, radiation effects)
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