Effects of gamma-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy.

Abstract

Effects of gamma-interferon (IFN-gamma) on immune parameters in the 9L gliosarcoma model were examined. IFN-gamma increased class I major histocompatibility complex (MHC) expression in 9L cells in vitro. In vivo, intratumor injections of IFN-gamma led to increased numbers of inflammatory cells within the tumor and class II+ mononuclear phagocytes at its periphery, and increased MHC class I or II expression by endothelial and ependymal cells. Class I expression in 9L cells themselves was not increased. This suggests that there may be inhibition of class I induction in vivo for certain cell types, for which immunotherapies based on non-MHC restricted mechanisms may be more effective.

• Authors: P Y Wen, M A Lampson, L A Lampson
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 36 Issue 1 Pg. 57-68 (Jan 1992) ISSN: 0165-5728 [Print] Netherlands
• PMID: 1735769 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Histocompatibility Antigens
• Interferon-gamma

Topics

• Animals
• Brain Neoplasms (immunology, pathology, therapy)
• Cell Movement (drug effects)
• Glioma (immunology, pathology, therapy)
• Histocompatibility Antigens (immunology)
• Humans
• Immunotherapy (methods)
• Injections
• Interferon-gamma (administration & dosage, therapeutic use)
• Lymphocytes (physiology)
• Male
• Rats
• Rats, Inbred F344
• Skin Neoplasms (therapy)
• Tumor Cells, Cultured