Acute silicosis responding to corticosteroid therapy.

Abstract

The course of acute silicosis usually is relentlessly progressive. Death results from cor pulmonale and respiratory failure, with mycobacterial infection a frequent serious complication. Attempts to treat the illness generally have been unavailing. We report an unusual case of acute silicosis in which improvement in clinical status, chest x-ray film findings and pulmonary function occurred following therapy with corticosteroids. To our knowledge, this is the first such case reported in the medical literature.

• Authors: G B Goodman, P D Kaplan, I Stachura, V Castranova, W H Pailes, N L Lapp
• Journal: Chest (Chest) Vol. 101 Issue 2 Pg. 366-70 (Feb 1992) ISSN: 0012-3692 [Print] United States
• PMID: 1735256 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisone

Topics

• Acute Disease
• Adult
• Humans
• Lung (diagnostic imaging, pathology)
• Male
• Prednisone (therapeutic use)
• Radiography
• Respiratory Mechanics
• Silicosis (diagnostic imaging, drug therapy, pathology, physiopathology)