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[Lacrimal proteins electrophoretic analysis--diagnostic method in secondary Sjogren syndrome].

AbstractPURPOSE:
We analysed and compared electrophoretic tear protein patterns of healthy subjects and patients with different autoimmune diseases associated with secondary Sjogren's syndrome.
MATERIALS AND METHODS:
Tears were collected using the Schirmer's method. Proteins were separated by sodium-dodecyl sulfate poliacrylamide gel electrophoresis. The lanes were stained by Coomassie blue and/or silver.
RESULTS:
Lactoferrin, albumin, lipocalin and lysozyme were found to be the main components being identified using molecular weight markers.
CONCLUSIONS:
Electrophoretic analysis of tear proteins patterns is a fast, reproducible and simple method which provides information about the possibility of lacrimal gland involvement in autoimmmune diseases.
AuthorsViorica Mădălina Cojocaru, Coziana Ciurtin, Elena Puchianu, Felicia Antohe
JournalOftalmologia (Bucharest, Romania : 1990) (Oftalmologia) Vol. 50 Issue 4 Pg. 60-3 ( 2006) ISSN: 1220-0875 [Print] Romania
Vernacular TitleAnaliza electroforetică a proteinelor lacrimale-- metodă de diagnostic a sindromului Sjogren secundar.
PMID17345806 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Albumins
  • Anti-Infective Agents
  • Carrier Proteins
  • Eye Proteins
  • LCN1 protein, human
  • Lipocalin 1
  • tear proteins
  • Muramidase
  • Lactoferrin
Topics
  • Albumins (analysis)
  • Anti-Infective Agents (analysis)
  • Autoimmune Diseases (diagnosis)
  • Carrier Proteins (analysis)
  • Case-Control Studies
  • Electrophoresis, Polyacrylamide Gel
  • Eye Proteins (analysis)
  • Humans
  • Lactoferrin (analysis)
  • Lipocalin 1
  • Muramidase (analysis)
  • Sensitivity and Specificity
  • Sjogren's Syndrome (diagnosis, immunology)
  • Tears (chemistry)

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