[Solitary fibrous tumor: a clinico-morphological and immunohistochemical study].

Abstract

Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphism and high mitotic index (more than 4 mitoses within 4 visual fields, at high magnification) were used as malignancy criteria:. Tumor histological pattern of "hemangiopericytic" variety could be reliably identified thanks to immunohistochemical procedure.

• Authors: E E Leenman, S D Popov, I V Dvorakovskaia, A I Arsen'ev, K M Pozharisskiĭ
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 52 Issue 6 Pg. 624-32 ( 2006) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 17338238 (Publication Type: Case Reports, Journal Article)

Chemical References

• 12E7 Antigen
• Actins
• Antigens, CD
• Antigens, CD34
• Biomarkers, Tumor
• CD99 protein, human
• Cell Adhesion Molecules
• Desmin
• S100 Proteins
• Vimentin

Topics

• 12E7 Antigen
• Actins (analysis)
• Aged
• Antigens, CD (analysis)
• Antigens, CD34 (analysis)
• Biomarkers, Tumor (analysis)
• Cell Adhesion Molecules (analysis)
• Child
• Desmin (analysis)
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Mitotic Index
• Necrosis
• Neoplasms, Fibrous Tissue (chemistry, pathology)
• Polymorphism, Genetic
• S100 Proteins (analysis)
• Vimentin (analysis)