Abstract | OBJECTIVE: DESIGN AND SETTING: The Helsinki Heart Study was a randomized, double-blind, 5-year clinical trial to test the efficacy of gemfibrozil in reducing the risk for coronary heart disease. Participants were randomized to receive either gemfibrozil (2046 patients) or placebo (2035 patients). Fatal and nonfatal myocardial infarction and sudden cardiac death were the main study end points. Serum samples were collected at 3-month intervals from all patients. PATIENTS: One hundred forty cardiac events occurred during the follow-up period. Serum samples from 103 case patients obtained 3 to 6 months before a cardiac end point were matched with those from controls for time point, locality, and treatment. Samples were tested for markers of chronic chlamydial infection. MEASUREMENTS: MAIN RESULTS: Using a conditional logistic regression model, odds ratios for the development of coronary heart disease were 2.7 (95% CI, 1.1 to 6.5) for elevated IgA titers, 2.1 (CI, 1.1 to 3.9) for the presence of immune complexes, and 2.9 (CI, 1.5 to 5.4) for the presence of both factors. If we adjusted for other coronary heart disease risk factors such as age, hypertension, and smoking, the corresponding values would be 2.3 (CI, 0.9 to 6.2), 1.8 (CI, 0.9 to 3.6), and 2.6 (CI, 1.3 to 5.2), respectively. CONCLUSION:
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Authors | P Saikku, M Leinonen, L Tenkanen, E Linnanmäki, M R Ekman, V Manninen, M Mänttäri, M H Frick, J K Huttunen |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 116
Issue 4
Pg. 273-8
(Feb 15 1992)
ISSN: 0003-4819 [Print] United States |
PMID | 1733381
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Antigen-Antibody Complex
- Immunoglobulin A
- Immunoglobulin G
- Lipopolysaccharides
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Topics |
- Adult
- Antibodies, Bacterial
(blood)
- Antigen-Antibody Complex
(blood, chemistry)
- Chlamydia Infections
(complications, immunology)
- Chlamydophila pneumoniae
(immunology)
- Chronic Disease
- Coronary Disease
(immunology, microbiology)
- Humans
- Immunoglobulin A
(blood)
- Immunoglobulin G
(blood)
- Lipopolysaccharides
(blood, immunology)
- Male
- Middle Aged
- Odds Ratio
- Prospective Studies
- Risk Factors
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