Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications.

Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as one of the common pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes a potential preventive and therapeutic target for cancer metastasis.
AuthorsSuyun Huang
JournalClinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 13 Issue 5 Pg. 1362-6 (Mar 1 2007) ISSN: 1078-0432 [Print] United States
PMID17332277 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
Chemical References
  • STAT3 Transcription Factor
  • Animals
  • Gene Expression Regulation, Neoplastic (physiology)
  • Humans
  • Neoplasm Invasiveness (physiopathology)
  • Neoplasm Metastasis (physiopathology)
  • Neoplasms (metabolism)
  • STAT3 Transcription Factor (metabolism)
  • Signal Transduction (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: