HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Risk factors for acute pulmonary edema in preterm delivery.

AbstractOBJECTIVE:
To determine the risk factors for pulmonary edema in women with preterm delivery.
STUDY DESIGN:
This was a case-controlled study of 52 (6.7%) cases with and 722 (93.3%) cases without pulmonary edema in a cohort of women who delivered between 24 and 33 weeks. Univariate and logistic regression analysis were used as indicated.
RESULTS:
Of subjects with pulmonary edema 98% received tocolytics while 94% had antenatal corticosteroid therapy versus 50% and 40% in controls. Significant positive associations of pulmonary edema only on univariate analysis were multiple pregnancy, earlier presenting gestational age, positive maternal cultures, small for gestational age while significant negative associations were indicated by preterm delivery and premature rupture of membranes. Independent predictors of pulmonary edema on logistic regression analysis were spontaneous preterm labor (odds ratio {OR}=10.9, p=0.026; 95% CI 1.3, 90), tocolytic therapy (OR=4.3, p=0.000; 95% CI 2.3, 8.4) especially magnesium sulfate and nifedipine, antenatal corticosteroid therapy (OR=2.3, p=0.002; 95% CI 1.3, 4), chorioamnionitis (OR=2.7, p=0.028; 95% CI 1.1, 6.5), blood product transfusion (OR=2.3, p=0.038; 95% CI 2.2, 8.4) and tobacco use (OR=2.5, p=0.016; 95% CI 1.2, 5.4).
CONCLUSIONS:
In mothers delivering prematurely, pulmonary edema is more likely with spontaneous preterm labor, smokers, infections or those receiving blood transfusions. It occurs almost exclusively in patients treated with antenatal corticosteroids and tocolytic medication.
AuthorsDotun Ogunyemi
JournalEuropean journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 133 Issue 2 Pg. 143-7 (Aug 2007) ISSN: 0301-2115 [Print] Ireland
PMID17329009 (Publication Type: Journal Article)
Topics
  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Obstetric Labor, Premature
  • Pregnancy
  • Pregnancy Outcome (epidemiology)
  • Prognosis
  • Pulmonary Edema (epidemiology)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: