Abstract | OBJECTIVE: To determine the risk factors for pulmonary edema in women with preterm delivery. STUDY DESIGN: This was a case-controlled study of 52 (6.7%) cases with and 722 (93.3%) cases without pulmonary edema in a cohort of women who delivered between 24 and 33 weeks. Univariate and logistic regression analysis were used as indicated. RESULTS: Of subjects with pulmonary edema 98% received tocolytics while 94% had antenatal corticosteroid therapy versus 50% and 40% in controls. Significant positive associations of pulmonary edema only on univariate analysis were multiple pregnancy, earlier presenting gestational age, positive maternal cultures, small for gestational age while significant negative associations were indicated by preterm delivery and premature rupture of membranes. Independent predictors of pulmonary edema on logistic regression analysis were spontaneous preterm labor (odds ratio {OR}=10.9, p=0.026; 95% CI 1.3, 90), tocolytic therapy (OR=4.3, p=0.000; 95% CI 2.3, 8.4) especially magnesium sulfate and nifedipine, antenatal corticosteroid therapy (OR=2.3, p=0.002; 95% CI 1.3, 4), chorioamnionitis (OR=2.7, p=0.028; 95% CI 1.1, 6.5), blood product transfusion (OR=2.3, p=0.038; 95% CI 2.2, 8.4) and tobacco use (OR=2.5, p=0.016; 95% CI 1.2, 5.4). CONCLUSIONS:
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Authors | Dotun Ogunyemi |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 133
Issue 2
Pg. 143-7
(Aug 2007)
ISSN: 0301-2115 [Print] Ireland |
PMID | 17329009
(Publication Type: Journal Article)
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Topics |
- Adult
- Case-Control Studies
- Female
- Humans
- Obstetric Labor, Premature
- Pregnancy
- Pregnancy Outcome
(epidemiology)
- Prognosis
- Pulmonary Edema
(epidemiology)
- Risk Factors
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