Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: RESULTS: All treatments similarly and significantly improved symptoms including hirsutism and menstrual cycle length. Insulin resistance was improved by metformin and worsened by the high-dose OCP. Arterial stiffness worsened in the higher-dose OCP group (PWV 7.46 vs. 8.03 m/s, P < 0.05), related primarily to the increased insulin resistance. CONCLUSIONS: In overweight women with PCOS, metformin and low- and high-dose OCP preparations have similar efficacy but differential effects on insulin resistance and arterial function. These findings suggest that a low-dose OCP preparation may be preferable if contraception is needed and that metformin should be considered for symptomatic management, particularly in women with additional metabolic and cardiovascular risk factors.
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Authors | Caroline Meyer, Barry P McGrath, Helena Jane Teede |
Journal | Diabetes care
(Diabetes Care)
Vol. 30
Issue 3
Pg. 471-8
(Mar 2007)
ISSN: 1935-5548 [Electronic] United States |
PMID | 17327307
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contraceptives, Oral
- Insulin
- Metformin
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Topics |
- Adult
- Area Under Curve
- Body Mass Index
- Cardiovascular Physiological Phenomena
- Contraceptives, Oral
(therapeutic use)
- Female
- Femoral Artery
(physiopathology)
- Glucose Tolerance Test
- Homeostasis
- Humans
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Metformin
(therapeutic use)
- Models, Biological
- Overweight
- Polycystic Ovary Syndrome
(blood, drug therapy, physiopathology)
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