[Clinical characters and prognosis of postpartum choriocarcinoma].

Abstract

OBJECTIVE:

To analyze the clinical characters and prognosis of postpartum choriocarcinoma.

METHODS:

Retrospective analysis of 103 patients diagnosed with postpartum choriocarcinoma in Peking Union Medical College Hospital between 1985 and 2005 was performed.

RESULTS:

In a total of 103 cases of postpartum choriocarcinoma treated with multiagent cytotoxic chemotherapy and combined modality therapy, 92 patients (89.3%) achieved a complete remission while 2 patients had a partial remission, and 9 patients died. Regarding 25 cases with chemorefractory choriocarcinoma and 4 relapsed cases, 18 and 3 cases achieved a complete remission respectively. According to the new International Federation of Gynecology and Obstetrics (FIGO) 2000 staging and risk factor scoring system, 17 cases were at FIGO stage I, 8 cases at stage II, 56 cases at stage III, and 22 cases at stage IV. Complete remission was achieved in 100%, 8/8, 95% and 64% respectively. Thirty-five cases in low risk group had FIGO scores < or = 6, and all achieved a complete remission. Of 68 cases in high risk group with FIGO scores > or = 7, 57 (84%) of them obtained a complete remission. There were significant differences in the two groups (P < 0.05).

CONCLUSION:

Postpartum choriocarcinoma could have an increasing probability of cure with early diagnosis and the use of modern multiagent cytotoxic chemotherapy and combined modality therapy.

• Authors: Cheng-Zhi Lei, Yang Xiang, Xi-Run Wan, Jun-Jun Yang, Quan-Cai Cui, Feng-Zhi Feng, Xiu-Yu Yang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 41 Issue 11 Pg. 752-5 (Nov 2006) ISSN: 0529-567X [Print] China
• PMID: 17327033 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chorionic Gonadotropin, beta Subunit, Human
• Dactinomycin
• Fluorouracil

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Choriocarcinoma (drug therapy, surgery)
• Chorionic Gonadotropin, beta Subunit, Human (blood)
• Combined Modality Therapy
• Dactinomycin (administration & dosage)
• Drug Resistance, Neoplasm
• Female
• Fluorouracil (administration & dosage)
• Humans
• Hysterectomy
• Middle Aged
• Postpartum Period
• Prognosis
• Retrospective Studies
• Treatment Outcome
• Uterine Neoplasms (drug therapy, surgery)