Abstract | BACKGROUND AND AIM: MATERIAL AND METHODS: One hundred patients treated with radionuclide bone palliation therapy were analysed. The study population consisted of 60 male patients with advanced prostate carcinoma and 40 female patients with advanced breast carcinoma. Fifty patients (30 men and 20 women) were treated with Sr (150 MBq). The other 50 patients were treated with Sm-EDTMP (37 MBq x kg). The treatment efficacy was evaluated by a visual analogue scale (VAS), Karnofsky performance scale, and dosage of analgesic drugs used. RESULTS: Complete pain relief was found in 40% of women and 40% of men treated using Sm-EDTMP and in 25% of women and 33% of men treated with Sr. No analgesic effect occurred in 20% of patients. A better analgesic effect was found in cases of osteoblastic metastases compared to mixed metastases. Statistically significant reduction of pain intensity, use of analgesic drugs and improvement of performance in Karnofsky scale was found in cases of both radionuclides. CONCLUSIONS:
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Authors | Maciej Baczyk, Rafał Czepczyński, Piotr Milecki, Marlena Pisarek, Robert Oleksa, Jerzy Sowiński |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 28
Issue 4
Pg. 245-50
(Apr 2007)
ISSN: 0143-3636 [Print] England |
PMID | 17325585
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Organometallic Compounds
- Organophosphorus Compounds
- Radiopharmaceuticals
- Strontium Radioisotopes
- samarium Sm-153 lexidronam
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Topics |
- Aged
- Bone Neoplasms
(complications, radiotherapy, secondary)
- Breast Neoplasms
(complications, radiotherapy)
- Carcinoma
(complications, radiotherapy, secondary)
- Female
- Humans
- Male
- Middle Aged
- Organometallic Compounds
(therapeutic use)
- Organophosphorus Compounds
(therapeutic use)
- Pain
(etiology, prevention & control)
- Pain Measurement
- Palliative Care
(methods)
- Prostatic Neoplasms
(complications, radiotherapy)
- Radiopharmaceuticals
(therapeutic use)
- Strontium Radioisotopes
(therapeutic use)
- Treatment Outcome
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