Topical capsaicin for treatment of hemodialysis-related pruritus.

Abstract

Pruritus is a significant problem for many patients undergoing long-term hemodialysis. Topical capsaicin depletes and prevents the reaccumulation of substance P in peripheral sensory neurons. Substance P functions in the transmission of pain and probably itch sensations. An open-label, uncontrolled trial and a double-blind, vehicle-controlled trial were conducted to evaluate the efficacy and safety of capsaicin 0.025% cream in the treatment of localized areas of pruritus in patients undergoing long-term hemodialysis. Eight of nine evaluable patients in the open-label trial reported marked relief or complete resolution of itching during the study period, and two of five evaluable patients in the double-blind trial reported complete resolution of itching in the capsaicin-treated arm with no or minimal improvement in the vehicle-treated arm. Twelve patients in the open-label trial and two in the double-blind trial were unevaluable. No serious treatment-related adverse reactions occurred.

• Authors: D L Breneman, J S Cardone, R F Blumsack, R M Lather, E A Searle, V E Pollack
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 26 Issue 1 Pg. 91-4 (Jan 1992) ISSN: 0190-9622 [Print] United States
• PMID: 1732343 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Capsaicin

Topics

• Administration, Topical
• Adult
• Aged
• Capsaicin (administration & dosage, adverse effects)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Pruritus (drug therapy, etiology)
• Renal Dialysis (adverse effects)