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The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.

Abstract
The 5-HT(1A) receptor agonist 8-OH-DPAT (0.5mg/kg) enhances behavioral recovery when administered 15min after experimental traumatic brain injury (TBI). To determine if benefits are still attainable at clinically relevant times, treatment was delayed 1 and 2h post-TBI and motor/cognitive performance was compared to early (i.e., 15min) administration. No differences were observed among the vehicle and 8-OH-DPAT groups treated at 1 and 2h, but all three were significantly impaired versus early 8-OH-DPAT. The data suggest that an early and narrow critical period exists for the behavioral recovery afforded by a single 8-OH-DPAT treatment paradigm. The critical window corresponds to the well documented TBI-induced glutamate increase, suggesting that 8-OH-DPAT may be conferring neuroprotection by attenuating this acute deleterious surge.
AuthorsJeffrey P Cheng, Haris A Aslam, Ann N Hoffman, Ross D Zafonte, Anthony E Kline
JournalNeuroscience letters (Neurosci Lett) Vol. 416 Issue 2 Pg. 165-8 (Apr 12 2007) ISSN: 0304-3940 [Print] Ireland
PMID17321680 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Serotonin Receptor Agonists
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
Topics
  • 8-Hydroxy-2-(di-n-propylamino)tetralin (administration & dosage)
  • Animals
  • Behavior, Animal (drug effects)
  • Brain Injuries (drug therapy)
  • Male
  • Maze Learning (drug effects)
  • Motor Activity (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin Receptor Agonists (administration & dosage)
  • Time Factors

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