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Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease.

Abstract
Certain autoantibodies are characteristic of autoimmune disease manifestations and contribute to organ pathology. The presence of high-titer antibodies to U1-RNP are associated with mixed connective tissue disease, although these antibodies may also be present in systemic lupus erythematosus and systemic sclerosis. However, the role of antibodies to U1-RNP in the pathogenesis of connective tissue disease remains unclear. Data from recent experimental studies promote the hypothesis that U1-RNP antibodies participate in both innate and adaptive immune responses, implicating them in the pathogenesis of connective tissue disease.
AuthorsMichael P Keith, Chantal Moratz, George C Tsokos
JournalAutoimmunity reviews (Autoimmun Rev) Vol. 6 Issue 4 Pg. 232-6 (Mar 2007) ISSN: 1568-9972 [Print] Netherlands
PMID17317614 (Publication Type: Journal Article, Review)
Chemical References
  • Antibodies, Antinuclear
  • Ribonucleoprotein, U1 Small Nuclear
  • Toll-Like Receptors
Topics
  • Animals
  • Antibodies, Antinuclear (immunology)
  • Connective Tissue Diseases (immunology)
  • Humans
  • Ribonucleoprotein, U1 Small Nuclear (immunology)
  • Toll-Like Receptors (immunology)

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