Safety and tolerability of long lasting LDL-apheresis in familial hyperlipoproteinemia.

Abstract

The aim of this work is to arbitrate the incidence of side effects and tolerability of long lasting LDL-apheresis in familial hyperlipoproteinemia. 1200 procedures were performed and the last 463 of them were evaluated. An immunoadsorption method of LDL-apheresis was used (continuous blood cell separator Cobe Spectra; secondary device: automated adsorption-desorption ADA, Medicap; absorption columns: Lipopak). As a whole, 6.26% adverse events were found and subsequently resolved by standard symptomatic therapy. Vaso-vagal reactions (symptoms of neurovegetative lability) were the most common adverse effects, presented as malaise, weakness, slight and short-term drop in blood pressure or other general signs. They were all well controlled by symptomatic therapy. We conclude that LDL-apheresis in the hands of experienced personnel is a safe procedure. An acceptable procedure duration limit, balancing the possibility to achieve a targeted cholesterol level while still maintaining an acceptable patient tolerance, was confirmed to be 4 hours.

• Authors: Milan Bláha, Melanie Cermanová, Vladimír Bláha, Martin Blazek, Jaroslav Malý, Oldrich Siroký, Dagmar Solichová, Stanislav Filip, Vít Rehácek
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 11 Issue 1 Pg. 9-15 (Feb 2007) ISSN: 1744-9979 [Print] Australia
• PMID: 17309569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, LDL

Topics

• Adolescent
• Adsorption
• Adult
• Cholesterol, LDL (blood)
• Female
• Humans
• Hyperlipoproteinemias (blood, therapy)
• Male
• Middle Aged
• Plasmapheresis