Is rheumatoid arthritis a disease that starts in the intestine? A pilot study comparing an elemental diet with oral prednisolone.

Abstract

OBJECTIVES:

This pilot study aimed to determine if an elemental diet could be used to treat patients with active rheumatoid arthritis and to compare its effect to that of oral prednisolone.

METHODS:

Thirty patients with active rheumatoid arthritis were randomly allocated to 2 weeks of treatment with an elemental diet (n = 21) or oral prednisolone 15 mg/day (n = 9). Assessments of duration of early morning stiffness (EMS), pain on a 10 cm visual analog scale (VAS), the Ritchie articular index (RAI), swollen joint score, the Stanford Health Assessment Questionnaire, global patient and physician assessment, body weight, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and haemoglobin, were made at 0, 2, 4 and 6 weeks.

RESULTS:

All clinical parameters improved in both groups (p<0.05) except the swollen joint score in the elemental diet group. An improvement of greater than 20% in EMS, VAS and RAI occurred in 72% of the elemental diet group and 78% of the prednisolone group. ESR, CRP and haemoglobin improved in the steroid group only (p<0.05).

CONCLUSIONS:

An elemental diet for 2 weeks resulted in a clinical improvement in patients with active rheumatoid arthritis, and was as effective as a course of oral prednisolone 15 mg daily in improving subjective clinical parameters. This study supports the concept that rheumatoid arthritis may be a reaction to a food antigen(s) and that the disease process starts within the intestine.

• Authors: Thrasyvoulos Podas, Jeremy M D Nightingale, Roger Oldham, S Roy, Nicholas J Sheehan, John F Mayberry
• Journal: Postgraduate medical journal (Postgrad Med J) Vol. 83 Issue 976 Pg. 128-31 (Feb 2007) ISSN: 1469-0756 [Electronic] England
• PMID: 17308218 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Prednisolone

Topics

• Administration, Oral
• Anti-Inflammatory Agents (administration & dosage)
• Arthritis, Rheumatoid (diet therapy, drug therapy, etiology)
• Female
• Food, Formulated
• Humans
• Male
• Middle Aged
• Pilot Projects
• Prednisolone (administration & dosage)
• Treatment Outcome