Abstract |
A multicenter Canadian study enrolled 74 persons to compare low-dose cefotaxime at 1 g every 8 hr to ceftriaxone 1 g every 12 hr in patients with nosocomial pneumonia. Of 57 evaluable patients (30 cefotaxime and 27 ceftriaxone) in this preliminary report, 93% responded to therapy in both groups. Ceftriaxone patients tended to have more side effects (14.2%). This study is continuing to accrue patients to achieve 100 evaluable patients. Interim data, however, support the continued use of low-dose cefotaxime as an appropriate alternative for clinically effective and cost-effective management of nosocomially acquired pneumonia.
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Authors | G E Garber, P Auger, R M Chan, J M Conly, S D Shafran, M Gerson |
Journal | Diagnostic microbiology and infectious disease
(Diagn Microbiol Infect Dis)
Vol. 15
Issue 1
Pg. 85-8
(Jan 1992)
ISSN: 0732-8893 [Print] United States |
PMID | 1730189
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cefotaxime
(administration & dosage, therapeutic use)
- Ceftriaxone
(administration & dosage, therapeutic use)
- Cross Infection
(drug therapy)
- Female
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Pneumonia
(drug therapy)
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